Reverse-Transmigrated Neutrophils in Zebrafish
Developed a transgenic zebrafish line and model to track intestine-derived neutrophils after inflammation, examining migration and oxidative stress as possible contributors to extra-intestinal IBD manifestations.
Neuroendocrine-Epithelial Interactions
Analyzing public single-cell RNA-sequencing datasets for evidence of neuroendocrine regulation in intestinal epithelial cells, with study design and high-performance computing collaboration at SickKids.
Ultra-Processed Foods and IBD
Integrated multi-omics data in R and developed XGBoost, Random Forest, and Extra Trees models to predict IBD incidence. Complementary cell-culture work examines epithelial barrier integrity. UK Biobank analysis is pending data access.
Spatial Proteomics in IBD
Independently conceived and wrote a narrative review on tissue architecture, disease mechanisms, and therapeutic opportunities in IBD. Manuscript in submission to Frontiers in Immunology.
Imaging Mass Cytometry of Liver Allograft Fibrosis
Developed an R workflow for IMC preprocessing, segmentation, phenotyping, and dimensional analysis to compare pre- and post-transplant biopsies. Presented at two conferences; manuscript in preparation.
Multi-Agent AI for Liver Donor Suitability
Built a Python multi-agent transplant selection committee using retrieval augmented generation and donor guidelines, processing clinical data from over 40,000 donors to investigate opportunities to reduce liver discard.